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Assay Designs

Product Launch

Osteopontin (rodent) EIA Kit

Assay Designs™ is happy to announce the launch of a ready-to-use enzyme immunoassay kit for the measurement of Osteopontin culture supernates, EDTA plasma, and urine samples from mouse and rat origins. 

 Osteopontin (OPN) is an acidic extracellular matrix cell adhesion protein that is relatively abundant not only in bone matrix, plasma, urine, and milk, but is also found in malignant and atherogenic tissues. Phosphorylation, glycosylation and calcium modifications allow intact and fragmented Osteopontin to direct a variety of diverse responses including tissue remodeling, inflammation and cell survival. Plasma Osteopontin has been shown to be a positive indicator of colon and lung cancers as well as metastatic carcinomas. The notable presence of Osteopontin in a variety of tumors is strongly correlated to pathological stage, suggesting its critical role in tumor invasiveness, progression and metastasis. In addition, Osteopontin inhibits inducible nitric oxide synthase activity, thereby protecting tumor cells from NO-mediated macrophage cytotoxic attack. Osteopontin is found in atherosclerotic plaques and may drive a number of diabetic vascular pathologies.

Product Features & Benefits

• Accurate – parallelism data demonstrates the recombinant standard accurately reflects natural osteopontin
• Fast – results from up to 40 samples in duplicate in just 3 hours
• Easy-to-use – color-coded reagents reduce error
• Convenient – ready-to-use reagents and pre-coated 96-well plate

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Last modified: 05/29/09